Levi Spiegelberg followed his brother Solomon to Santa Fe, New Mexico in 1848. Together they formed the partnership of Spiegelberg Brothers, an extremely successful merchant enterprise. Like many pioneer Jewish men, Levi wished to marry within his faith. Those who could afford the expense, often returned to Europe to find a Jewish bride. Betty married Levi in 1848. She arrived in Santa Fe, New Mexico in the early 1860's after taking the railroad to the end of the Missouri and then traveling up the steep Santa Fe Tail by ox train.